Tiny molecular change linked to psychiatric illness

Based on this research, it appears that a tiny change on the molecular level in the brain cells of babies can lead to all sorts of psychiatric problems later in life.  Drinking, physical abuse, drug use or illness in the mother, all can cause illnesses such as schizophrenia and some forms of autism and bipolar disorders for a fetus.  We're talking of changes of the most basic chemical type within the developing fetal cells of a newborn leading to a lifetime of mental issues.

 This information, perhaps not directly related to a character in your story, can help you understand how this person became the way they are.  In the debate of nature versus nurture, it appears that nature is the culprit.  This asks the question, "can talk therapy cure such a disease when its cause is genetic?"  I can't answer this.

 From a human standpoint, since the stem cells of people with a psychiatric problem were used to make this "diagnosis", is there hope that a stem cell therapy may be available some day in the future.  

 Come to think of it, this could be core of a plot for a nice piece of fiction, don't you think?

 Here's the report:

 A single molecular mechanism in the developing brain has been identified that sheds light on how cells may go awry when exposed to a variety of different environmental insults. The findings suggest that different types of stressors prenatally activate a single molecular trigger in brain cells that may make exposed individuals susceptible to late-onset neuropsychiatric disorders.

 Children whose mothers were exposed during pregnancy to any one of a variety of environmental stressors -- such as trauma, illness, and alcohol or drug abuse -- become susceptible to various psychiatric disorders later in life such as schizophrenia, post-traumatic stress disorder, and some forms of autism and bipolar disorders.

Suggested reading
click on image
Yale University researchers have identified a single molecular mechanism in the developing brain that sheds light on how cells may go awry when exposed to a variety of different environmental insults. The findings suggest that different types of stressors prenatally activate a single molecular trigger in brain cells that may make exposed individuals susceptible to late-onset neuropsychiatric disorders.

 In addition, researchers created stem cells -- which are capable of becoming neurons -- from biopsies of individuals diagnosed with schizophrenia. Genes from these "schizophrenic" stem cells responded more dramatically when exposed to environmental insults than stem cells obtained from non-schizophrenic individuals. The findings support to the thesis that stress induces vulnerable cells to malfunction.
*  *  *  *  *

 Story Source: Materials provided by Yale University, written by Bill Hathaway from the research by Kazue Hashimoto-Torii, Masaaki Torii, Mitsuaki Fujimoto, Akira Nakai, Rachid El Fatimy, Valerie Mezger, Min J. Ju, Seiji Ishii, Shih-hui Chao, Kristen J. Brennand, Fred H. Gage, Pasko Rakic. Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders. Neuron, 2014

Comments

Post a Comment

Popular posts from this blog

How the lives of Georgian gaolbirds and highwaymen shaped modern Britain

Image
Writing historical fiction requires solid research of available materials and databases.  The key word here is available.   So news of a new publicly accessible database that allows an author to research a very interesting past era is priceless almost beyond words.   I expect some exciting fiction to come out of this announcement. Here's the story, with a link to the source in the attribution. *  *  *  *  * London Lives, a landmark project led by Professor Bob Shoemaker from the University of Sheffield and Professor Tim Hitchcock from the University of Sussex, has uncovered a mass of extraordinary new evidence which reveals how the lives of thousands of 18th-century poor and criminal Londoners helped shape modern Britain. Based on evidence made available in a publicly available database, the study sheds new light on the everyday lives of thieves, prostitutes, vagrants, highwaymen, con-men, paupers and jailbirds, revealing how their daily fight for survival led to t
Read more

An unexpected way to recover from a breakup

Image
Breaking up is truly hard to do. And recovery from a breakup can be even harder. Your friends may counsel you to put the whole thing out of your mind. But new research suggests that repeatedly reflecting on a break-up -- even through participation in a research study -- actually speeds emotional recovery. "Breakups are ubiquitous -- most adults have experienced at least one in their life -- and are typically very distressing," says Grace Larson of Northwestern University. After studying divorce and breakups for years using longitudinal, multi-method designs, Larson and her then-adviser David Sbarra of the University of Arizona wanted to study whether these research techniques on their own were affecting participants. One concern they had was that the studies could be harming participants, Larson says. "At first glance, it might seem like repeatedly reminding participants that they had just broken up -- and asking them to describe the breakup over and over --
Read more

Greek Bronze Age ended 100 years earlier than thought

Image
Source: www.shef.ac.uk The charred remains of Assiros Toumba in Greece. Writing historical fiction set in the Greek Bronze Age?  Or simply enjoy reading this genre'?  Here's a study you may find interesting. C onventional estimates for the collapse of the Aegean civilization may be incorrect by up to a century, according to new radiocarbon analyses. While historical chronologies traditionally place the end of the Greek Bronze Age at around 1025 BCE, this latest research suggests a date 70 to 100 years earlier. www.weather-forecast.com Archaeologists from the University of Birmingham selected 60 samples of animal bones, plant remains and building timbers, excavated at Assiros in northern Greece, to be radiocarbon dated and correlated with 95.4% accuracy using Bayesian statistical methodology at the University of Oxford and the Akademie der Wissenschaften Heidelberg, Germany. Researcher Dr Ken Wardle says, 'These new results tell a story that is totall
Read more

Mood Instability and Your Characters

Image
You're putting together a character who's mood simply bounces all over the place, happy one moment, in a fit of rage the next.  Researchers at King's College London note that this sort of mood instability is part of a number of mental health disorders.  So how do you structure the personality and behavior of a character like this?  Below is the King's College report, along with a brief description from mentalhealth.com, of typical behavior, sometimes in the extreme, of a person who is very emotionally unstable.  This is offered strictly as a guide for crafting character in fiction - and NOT for the amateur diagnosis of the state of someone's mental health.  That is always best left to trained professionals. Another note about emotionally unstable behavior:  as any parent will tell you, this is how adolescents and teen-agers often behave.  It's a normal part of growing up - but it is a matter of degree .  In the extreme, however, this behavior can be diag
Read more

Remember faces but not names? You got it wrong.

Image
Source:   Daily Excelsior So, you think you're good at remembering faces, but terrible with names? New research has revealed we are actually better at remembering names than faces The cringe-worthy experience of not being able to remember an acquaintance's name leads many of us to believe we are terrible with names. However, new research has revealed this intuition is misleading; we are actually better at remembering names than faces. With the Christmas party season fast approaching, there will be plenty of opportunity to re-live the familiar, and excruciatingly-awkward, social situation of not being able to remember an acquaintance's name. This cringe-worthy experience leads many of us to believe we are terrible at remembering names. However, new research has revealed this intuition is misleading; we are actually better at remembering names than faces. The authors of the study, from the University of York, suggest that when we castigate ourselves f
Read more